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KMID : 1144320190510020177
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감염과 화학요법
2019 Volume.51 No. 2 p.177 ~ p.182
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Nosocomial Outbreak Caused by NDM-5 and OXA-181 Carbapenemase Co-producing Escherichia coli
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Ahn Kwang-Jin
Hwang Gyu-Yel
Kim Young-Keun
Kim Hyo-Youl
Jeong Hye-Ran
Hong Jun-Sung
Uh Young
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Abstract
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Carbapenemase-producing Enterobacteriaceae (CPE) is an important and increasing threat to global health. From July to September 2017, 20 inpatients at a tertiary care hospital in Korea were either colonized or infected with carbapenem-resistant Escherichia coli strains. All of E. coli isolates co-produced blaNDM-5 and blaOXA-181 carbapenemase genes and shared ≥88% clonal relatedness on the basis of a cladistic calculation of the distribution of pulsed-field gel electrophoresis patterns. Rapid detection of CPE is one of the most important factors to prevent CPE dissemination because it takes long time for CPE to become negative.
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KEYWORD
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New Delhi metallo-enzyme carbapenemase, Oxacillin-hydrolyzing beta-lactamase, Escherichia coli, Carbapenemase-producing Enterobacteriaceae, Outbreak control
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